Small Nucleic Acid Drug

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Small nucleic acid drugs, composed of oligonucleotides, are a novel class of therapeutics distinct from small molecule and antibody drugs. The FDA has approved 6 siRNA and 9 ASO drugs, which primarily work by base-pairing with and inhibiting target mRNA in the cytoplasm to regulate protein expression and achieve therapeutic effects. These drugs expand the range of treatable targets and address "undruggable" and "un-targetable" challenges.
Tsingke has strategically developed in small nucleic acid drug solutions, establishing high-throughput synthesis, customized modification, and efficient purification platforms, providing both research-use-only (RUO) and good manufacturing practice (GMP) grade products and supporting investigational new drug (IND) applications. We are the key partner for researchers, accelerating the transition of small nucleic acid drugs from laboratory research to clinical therapies.
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Tsingke offers a variety of siRNA synthesis services ranging from µg to kg scales, with various modification options including 2'-F, 2'-OMe, 2'-O-MOE, 2'-O-C16, VP, cEt, GalNAc, GNA, UNA, cholesterol, and fluorescent labels. All products come with MS detection or customizable QC options to meet your needs from research-grade to clinical-grade applications.
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SynbioTech provides high-quality ASO synthesis services from µg to kg scales, with modification options including PS, LNA, 2'-OMe, and fluorescent labels. All products feature MS detection and provide a range of customizable QC options to suit your needs, from research-grade to clinical-grade applications.
Why Choose Tsingke
Excellent Production
Comprehensive Solutions
Expertise and Innovation
Commercial Support
Tsingke has established high-standard production facilities to ensure manufacturing strictly adheres to relevant regulations and standards, guaranteeing high-quality and safe products.

Tsingke provides comprehensive solutions for small nucleic acid drug discovery, including target screening, drug design and synthesis, identification and validation of cell-level candidate drugs, toxicity evaluation, and optimization.

In CRO design and development, Tsingke has designed over 10,000 gene-specific siRNAs and has a rich talent pool, delivering over 100,000 siRNAs per year.
In assay development, Tsingke has pre-stocked over 13,000 overexpression genes, 20,000 shRNA plasmids, and 5,000 sgRNA plasmids, and has validated 5,000 ready-to-use primers. Tsingke offers high-quality, efficient qRT-PCR and Western blotting services to accelerate target screening and validation.

Tsingke supports IND application services, including regulatory consulting, project management, pharmaceutical documentation preparation, and IND application assistance, helping customers navigate the IND application process smoothly.
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