Structure of the human PKD1-PKD2 complex
The codon-optimized full-length cDNAs for human PKD1 and PKD2 were synthesized by Tsingke Company (hPKD1 [Uniprot: P98161-1]; hPKD2 [Uniprot: Q13563-1])).
Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction
Small interfering RNAs (siRNAs) targeting the Kdm4e (si-Kdm4e), Dux4 (si-Dux4), and scramble siRNA (si-NC) genes were constructed by Tsingke Biotechnology Co., Ltd. (Beijing, China).
MAMDC2, a gene highly expressed in microglia in experimental models of Alzheimers Disease, positively regulates the innate antiviral response during neurotropic virus infection
Our study uncovers the function of MAMDC2 in the innate antiviral response in microglia, revealing a potential mechanism linking HSV-1 and AD.-JOURNAL OF INFECTION, IF 38.637
CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity
Signal Transduction and Targeted, IF 38.104
Human-to-human transmission of Chlamydia psittaci in China, 2020: an epidemiological and aetiological investigation
In addition, a TaqMan-based qPCR assay was developed to test the clinical and duck samples with a set of probe and primers (synthesised by Tsingke Biotechnology, Beijing, China; appendix p 2) designed in this study, on the basis of the ompA gene sequence.
Strand-selective base editing of human mitochondrial DNA using mitoBEs
Wild-type TadA, TadA8e-V106W, MutH and its variants, Nt.BspD6I and other genes were synthesized as gene blocks and codon optimized for mammalian expression (Tsingke Biological Technology).